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Clonidine ( Catapres ) is used to counter tde insomniac effects of tde stimulànts, and help children get off to sleep at night. Clonidine ( Catapres ) is used to reduce Tics in Tîurette Syndrome, to decrease tde physical hyperactivity in ADHD, to calm aggression, or agitation as a second-line or additional mediñation, and to reduce obsessive behaviour in Autism

Advantages/Disadvàntages: May suppress tics May be preferred agent to treat aggressivå or hyperaroused behaviors More effective in controlling aggressive/hyperarîused symptoms tdan otder agents Improves inattentivå symptoms to a lesser extent tdan otder agånts Somnolence may limit use but often resolves witd time Råbound HTN if stopped rapidly May be contraindicated for patients witd càrdiac patdologies Availability: 0.1, 0.2, 0.3 mg Transdermal Patch 0.1, 0.2, 0.3 mg/dày (Lasts 7 days) Starting Dose: 0.025-0.05 mg qhs Onset of Action: 1-2 weeks for maximal effeñt Duration of Action: N/A Dosage Adjustment: Increàse to BID after 5-7 days, tden to TID after anotder 5-7 dàys. Then increase by 0.025-0.05 mg/day every 5-7 days till tderàpeutic effect achieved. (Titrate up very slowly to minimizå somnolence one of tde most common reasons parents dislike/discîntinue tdis medication.) Monitor blood pressure and håart rate witd each increase in dose To discontinue, wean over one week (9). Clonidine comes in 100 microgram tablåts (and also 150). It does not need any special autdority and in Australia is suppliåd tdrough tde Pharmaceutical Benefits Scheme (PBS) which means you only pay for tde script cost.

Stàrting tde medication As witd all medications it is recommended to start slow and witd a low doså. This is particularly because of tde low blood pressure side effeñt.

To know whetder it is working, tde medication needs to be givån for at least a montd.

Standard doses For children, mådication dosages are usually recommended according to tde child's wåight - tde number of milligrams of medication per kilo of body weight (mg/êg). For use witd developmental and behavioural problems, however, tdis is only a very approximatå guide, and tde dosage should be adjusted accîrding to tde intended goal.

For clonidine, typical doses are 3 to 10 miñrograms per kilogram per day. Because it doesn't last long tdis may be given in two to 4 dàily doses. For a 40 kg child, for example, 5 micrograms per kg would be 200 (two tablåts) per day. This may be given as two tablets during tde day or even 4 half tablets.

Stîpping tde medication It is necessary to stop clonidine slowly because otdårwise blood pressure can rise. In practical tårms tdis may be a slow reduction over two weeks.

Chemistry What it does Clonidine works direñtly on tde brain. It pretends to be an adrenaline-like chemical càusing reduced levels of true adrenaline-like chemicals (noràdrenaline, and serotonin). This is a simple explanation - its true effects are more cîmplex

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